PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
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PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, Gillis JE, Sen DR, Gaudiano EF, Al Abosy R, Freeman GJ, Haining WN, Sharpe AH. Nature Immunol. 2019 Oct; 20(10):1335-1347.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
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*These two authors contributed equally to this manuscript.
Loss of ADAR1 in tumors overcomes resistance to immune checkpoint blockade
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
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